Figure 2.
Biochemical analysis of WT, Klotho, HYP, and Klotho/HYP mice. A, Serum phosphate (n = 8–15 for each genotype); B, serum calcium (n = 8–12 for each genotype); C, serum FGF23 (n = 6–7 for each genotype); D, serum 1,25(OH)2D (n = 6–10 for each genotype); E, urinary phosphate excretion index (PEI) (urine [P]/serum [P] × urine [creatinine]) (n = 5–7 for each genotype); F, urinary calcium excretion as ratio to creatinine (milligrams per milligram) (n = 7 for all genotypes); G, serum osteocalcin levels (n = 5–8 for each genotype); H, serum concentrations of CTX (n = 5–8 for each genotype); I, serum PTH (n = 12–14 for each genotype). Differing lowercase letters indicate statistically significant differences (P < 0.05) between the groups. Bars with the same letters are not significantly different.