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. 2009 Dec 4;151(2):821–829. doi: 10.1210/en.2009-0980

Figure 1.

Figure 1

Cellular and in vitro T4 to T3 conversion by transiently expressed wild-type and P135S D2. A, Percent T4 to T3 conversion at variable free T4 concentrations. T4 deiodination was measured in six-well plates of HEK-293 cells transiently expressing wt D2 or D2 P135S. B, Cellular T3 production by the D2 enzymes. C, In vitro Vmax estimates for T3 production in sonicates of cells used in A at 20 mm DTT and either 10 nm T4 (wt D2) or 3 μm T4 (P135S D2). D, Physiological efficiency of cellular to in vitro T3 production by wild-type or P135S D2.