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. 2009 Dec 4;151(2):731–740. doi: 10.1210/en.2009-0955

Figure 3.

Figure 3

DNMT mRNA expression in female and male mouse cortex across early postnatal development. RNA was extracted from cortical tissue taken from female and male mice at PND 1, 4, 10, 18, and 25. RNA was reverse transcribed, and the resulting cDNA was used for real-time PCR using DNMT3A- or DNMT1-specific primers. A, DNMT3A mRNA expression was significantly increased in female cortex at PND 10 and 18. B, DNMT3A mRNA was also significantly increased in male cortex at PND 10 and 18. This increase in DNMT3A was only transient, and expression was no longer significantly increased at PND 25 in either female or male cortex. This increase is correlated with the increase in ERα mRNA expression in the cortex at PND 10. C, In female cortex, DNMT1 mRNA was significantly increased at PND 10, 18, and 25. D, In male cortex, DNMT1 mRNA was significantly increased at PND 18 and 25. Asterisks on the graphs indicate significant differences from PND1 (P < 0.05).