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. 2009 Dec 4;151(2):731–740. doi: 10.1210/en.2009-0955

Figure 5.

Figure 5

Mutations in MeCP2 change the developmental pattern of ERα mRNA and protein expression in the cortex. A, ERα mRNA expression in MeCP2 mutant females was significantly increased across early postnatal development. In contrast, in wild-type females, there was a significant decrease in ERα mRNA expression starting at PND 10. B, Western blot showing ERα protein expression in wild-type and MeCP2 mutant mice. C, Pyrosequencing analysis of genomic DNA from MeCP2 mutant female mice collected at PND 4, 18, and 25. C, Percent methylation of CG sites found in exon A. D, Percent methylation of CG sites found in exon C of the ERα gene. Asterisks indicate significant differences from PND 4 determined by Tukey post hoc tests after a two-way ANOVA (P < 0.05).