Table 3.

Differentially expressed genes in the molecularly defined ATLL

	Genes in classifier	Other differentially expressed genes
TCR signaling components and costimulatory/inhibitory molecules	TCRα, TCRβ, CD1ϵ, CTLA4, CD99, TRAC	ICOS, CD28, CD1B, CD1C, CD6, LAT, FYN, FYB
T-cell activation or differentiation	TNFRSF25(DR3), CD27, LEF1, NFATC1	IL2RA (CD25), IL4R, IL18R1, IL23R,IL12RB2, MAL, IL4R, GATA3
Proinflammatory	CCR4, CCL13, IL23R	IL6, IL6ST, CCL26
Melanoma-associated	MAGEA4, MAGEA9, MAGEA4B	MAGEB1, MAGEA3
Immune modulatory enzymes	PGDS (hematopoietic)	PTGER4, PTGER3
B cells	AICDA, MTA3
Previously published genes associated with ATLL	IKZF2, RGS13, PTHLH, RGS13, CADM1(TSLC1)	TCF4
HTLV-1 Tax target	c-Myc, TIAM1, PDE8B, DOK5, ARNT2, UST, PGDSMYCN, PDE8B, CEBPA, RGS13, PTHLH, SMARCA2, CD99, CADM1(TSLC1),CCR4, RGS2, SPINK2, RORA	IL2RA, CFLAR
Treg cell chemoattractant		CCL22, CCL20, CCL17
Cytotoxic molecules		TIA1

For abbreviations, see Table 2.

^*Only up-regulated representative genes are included in each signature.