Table 5.

Differentially expressed genes in the molecularly defined CT-PTCL

	Differentially expressed genes
Cytotoxic molecules and related genes	Granzyme-M, -K, -H, -B,-A; cathepsin-A, -B,-C, -D, -K, -L1, -S, -W; PRF1, GNLY, FADD, FASLG
Cytotoxic T- or NK-cell markers or associated transcription factors	CD244(2B4), FCGR3B (CD16), FCGR2C (CD32), CD226(DNAM-1), CD8α, CD8β, TBX21, eomesodermin (eomes)
Killer cell immunoglobulin-like or lectin-like receptor subfamily	KIR3DL1, KIR3DL2, KIR3DL3, KIR3DS1, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS, KIR2DS2, KIR2DS3, KIR2DS5, KLRB1, KLRC2, KLRC3, KLRC4, KLRD1, KLRF1, KLRK1
Chemokines/receptors associated with either CD8 + T cells or NK cells	CX3CR1, CXCR3, CXCL(-9, -10, -11), CCR1, CCR5, CXCR4, CCL2, CCL5, CCL8,CCL13,CCL18, XCL1, XCL2
Other cytokines (interleukin- and tumor necrosis factor–related)	IFNαR1, IFNγR1, IFNγR1, IFNγR2, IL1RN, IL1R1, IL1R2, IL13Rα1, IL17Rβ, IL18,IL18RAP, IL2Rβ, IL2Rγ, IL21R, IL22,IL27Rα, IL31Rα, IL32, ILF2, ILF3, TNFSF10, TNFSF13, TNFSF14, TNFRSF12α, TNFRSF1A, TNFRSF1B, TNFSF5IP1
Immunosuppression-associated genes	INDO, TGFβ1, TGFβR1, IL10, IL10Rβ, VSIG4, LILRB4, LILRB3, LILRB2, LILRB1,LILRA2, CD47
SAP/SLAM interaction	SH2DIA, LY96, LY6E, SLAM-5, -6, -7, -8

For abbreviations, see Table 2.

^*Only representative genes are included in each signature.