Figure 3.

BCL6 modulates multiple pathways in normal GC B cells. BCL6 represses multiple genes at different levels from the membrane surface (receptors), through signal transduction molecules, into the nucleus (transcription factors). Representative genes and gene families, found to be targeted by BCL6, are displayed for each pathway. Details on BCL6 targets and their pathways are reported in supplemental Figure 7. Several pathways (BCR and CD40 signaling; DNA damage response) have been previously reported to have a repressor function on BCL6, leading to its transcriptional down-regulation and protein degradation.