Figure 4.

CERK and T_H1/T_H2 cytokines. This schematic representation summarizes the current knowledge of the interplay between CERK and cytokines. The T_H1 cytokine INF-γ as well as LPS can repress CERK at transcriptional level in primary mouse macrophages which indicates that a T_H1 response may require initial down-regulation of CERK; this can be reversed by corticosteroids. The present work provides evidence that T_H2 cytokine production, IL-4 in particular, are dependent on CERK. Altogether, this suggests that CERK may polarize immune responses towards the T_H2 type.