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Epistatic model - mixed (EPI RD).
| Low risk | High risk | |
|---|---|---|
| r1 = 2; r2 = 4 | r1 = 5; r2 = 10 | |
| Theoretical penetrance matrix |  |
 |
| Neural network | ||
| Mean absolute difference E |  |
 |
| Sum | 0.2239 | 0.1563 |
| Logistic regression | ||
| Mean absolute difference E |  |
 |
| Sum | 0.5105 | 0.8658 |
| Logistic regression (design variables) | ||
| Mean absolute difference E |  |
 |
| Sum | 0.2799 | 0.2329 |
Mean absolute differences between theoretical and estimated penetrance matrices from 100 replications in the low and high risk scenario.
