Figure 4. Major gene ontology categories of genes that were differentially expressed due to culture of S. mansoni schistosomula in the presence of erythrocytes.

Gene ontologies representing the up-regulated genes in 3 h or 5 day schistosomula, and in both 3 h and 5 day schistosomula due to the presence of erythrocytes in the culture medium. P-values indicate the significance of the number and degree of differential expression within each category. Categories with a P-value ≤0.05 were deemed significant; to show the position of these sub-categories within the GO tree hierarchy, parent categories with a P-value >0.05 were also included. Categories with P-value >0.05 may indicate that only a small percentage of the genes were differentially expressed.