Table 1. Effects of telomerase inhibition and telomere shortening on the sensitivity of cancer cells to cytotoxic drugs.

Telomere length		TA	SK-N-MC
			IC50 of Vincristine (ng/ml)	IC50 of Doxorubicin ng/ml	IC50 of Cisplatinum ug/ml
Intact telomeres		+	8	49	0.13
		−	8	50	0.13
Shortened telomeres	∼75% of the original size	+	8.3	50	0.11
		−	8	49	0.11
	∼60% of the original size	+	7.9	49	0.07*
		−	7.85	49	0.07*

*- significance of P<0.05.

TA- telomerase activity.