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. 2010 Feb 9;5(2):e9111. doi: 10.1371/journal.pone.0009111

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Nemolato et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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a) Foetal pancreas: immunoreactivity for Tβ₄ is localized inside the islets of Langherans. Some of endocrine cells show the entire cytoplasm strongly immunoreactive for the peptide (arrows). Few Tβ₄-reactive cells are also present in the exocrine pancreas, inside the tubular structures (arrowhead). (Original Magnification ×400). b) Adult pancreas: the highest reactivity for Tβ₄ is observed in Langherans islet cells, which show diffuse fine granular deposits in their cytoplasm (arrows). (Original Magnification ×400).