Table 1.
RNA-binding proteins interacting with viral IRES.
| ITAFS | Effect on IRES activity | IRES targets | Functions in RNA metabolism |
|---|---|---|---|
| PTB | Stimulation | FMDV, EMCV, TMEV, PV, HRV, HAV, HCV | Splicing, polyadenylation, RNA stability, localization |
| DRBP76:NF45 | Repressor | HRV, HCV | Transcription, RNA transport, stability, viral replication |
| Ebp1/ PA2G4/ ITAF45 | Stimulation | FMDV, EMCV* | Transcription regulator |
| Unr | Stimulation | PV, HRV, HCV | Translation control |
| HSC70 | FMDV, HCV | Viral replication | |
| SRp20 | Stimulation | PV | Splicing |
| PCBP2 | Stimulation | PV, HRV, HAV, CVB3, FMDV*, | RNA stability, translation control |
| EMCV*, HCV | |||
| Gemin5 | Downregulation | FMDV, HCV | RNA-binding factor of SMN complex |
| hnRNP U | FMDV | RNA processing, stability, transcription | |
| hnRNP K | FMDV | Transcription, RNA stability, translation control | |
| DAZ1 | FMDV | Translation control | |
| G3BP | FMDV | Stress granules assembly | |
| Gpiap1 | FMDV, HCV | Transcription regulator, viral replication | |
| Nucleolin | Stimulation | PV, HRV, FMDV, HCV | Ribosomal RNA maturation, transport |
| FBP2 | Repressor | EV71 | RNA stability |
| eIF2C/Ago | FMDV | Silencing | |
| DHX9 | HRV, FMDV, HCV | RNA helicase | |
| DDX1 | FMDV | RNA helicase | |
| RACK1 | HCV | Ribosomal subunits joining | |
| IGF2BP1 | Stimulation | HCV | RNA localization, stability, translation control |
| La | Stimulation | PV, EMCV, HAV# | Transcription, translation control |
| NSAP1/ hnRNP Q | Stimulation | HCV | RNA stability, translation control, SGs component |
| hnRNP L | Stimulation | HCV | RNA stability, translation control |
| hnRNP D | Stimulation | HCV | RNA stability, translation control |
| hnRNPA/B | EV71, HCV | RNA processing, translation control | |
| GAPDH | Repressor | HAV | RNA transport, translation control |
| YB-BP1 | HCV | Transcription, RNA stability, translation control |
*No effect, #suppression.