Figure 9.

Beneficial effects of recombinant murine milk fat globule epidermal growth factor 8 (rmMFG-E8) after intestinal ischemia-reperfusion (I/R) in MFG-E8^−/− mice. The superior mesenteric artery (SMA) was occluded for 90 minutes, followed by 4 hours of reperfusion. Pulmonary levels of (A) TNF-α, (B) IL-1β, (C) IL-6, (D) MPO, and (E) cleaved caspase-3. (F) Representative blots for (E). Plasma levels of (G) lactate dehydrogenase (LDH), (H) alanine aminotransferase (ALT), and (I) aspartate aminotransferase (AST) were measured 4 hours after reperfusion. Data are expressed as means ± SEM. *P < 0.05 versus sham; #P < 0.05 versus vehicle by one-way analysis of variance and Student Newman Keul's test (n = 6 per group).