Fig. 2.

Effect of transglutaminase (TGase) inhibitors on disease activity and TGase 2 activity in Endotoxin-induced uveitis Rats were injected intraperitoneally with R2 peptide (KVLDGQDP,10 mg/kg, 500 µm), cystamine (CTM, 6.0 mg/kg, 500 µm) or dexamethasone (2 mg/kg) 30 minutes before and at the time of lipopolysaccharide administration. Disease activity and TGase 2 activity in aqueous humor were determined 24 hr later. (A) Grading of inflammation, showing a two-fold reduction in the R2-treated rats (mean±SD of 6-8 eyes). (B) Number of infiltrating cells on histologic sections, showing a three-fold reduction in the R2-treated group (mean±SD of 6-8 eyes). (C) TGase 2 activity, showing a ten-fold reduction in the R2 treated rats (mean±SD of 6-8 eyes). ^*Significantly different from control. p<0.001 by unpaired Student t-test.