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. 2010 Jan 4;12(1):1. doi: 10.1186/1532-429X-12-1

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Copyright ©2010 Tomasian et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(A) Low power photomicrograph (40×; H&E stain) demonstrates tumor (*) compressing left atrium (LA). (B) The tumor is comprised of nests of fairly uniform cells with moderate eosinophilic, granular cytoplasm (200×; H&E stain). (C) Marked cytologic atypia with pleomorphic nuclei and prominent nucleoli was focally present (400×; H&E stain) in addition to (D) increased number of mitoses (arrows) (400×; H&E stain). (E) Scattered foci of coagulative tumor necrosis (N) were also noted (200×; H&E stain). (F) The tumor exhibited diffuse, strong cytoplasmic positivity for synaptophysin immunostain (400×). (G) S100 immunostain highlights sustentacular cells surrounding nests of tumor cells (400×).