Table 4.
ICSD-2 criterion for low CSF hcrt-1 (<30% of the normal mean) applied on populations with narcolepsy without cataplexy
| STUDY | No. of Subjects |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Narcolepsy without cataplexy | Normal controls | Low CSF hcrt-1 | Recalculated ICSD-2 Cutoff Values | ||||||
| CSF hcrt-1 |
CSF hcrt-1 |
sens. | spec. | PPV | NPV | (low <30% of the normal mean) | |||
| low | normal | low | normal | (%) | (%) | (%) | (%) | ||
| Knudsen et al (this study) | 3 (3/3HLA+) | 11 (1/10HLA+)* | 0 | 27 | 19 | 100 | 100 | 73 | normal mean CSF hcrt-1 = 430 pg/mL low CSF hcrt-1 cutoff < 129 pg/mL *1/11 HLA-type was unavailable |
| Bourgin et al (2008)8 | 29* (24/29HLA+) | 133 (46/133HLA+) | 0 | 64 | 18 | 100 | 100 | 33 | normal mean CSF hcrt-1 = 363 pg/mL low CSF hcrt-1 cutoff < 108 pg/mL *5/29 are intermediate values close to low cutoff |
| Martinez-Rodriguez et al (2007)5 | 3 | 8 | 0 | 64* | 27 | 100 | 100 | 89 | normal mean CSF hcrt-1 = 381 pg/mL low CSF hcrt-1 cutoff < 114 pg/mL *linked to Stanford normal controls by reference CSF samples. 6/11 patients were HLA+ |
| Kanbayashi et al (2003)15, Oka et al (2006)17 | 5 (5/5HLA+) | 12 (4/12HLA+) | 0 | 12 | 29 | 100 | 100 | 50 | normal mean CSF hcrt-1 = 293 pg/mL low CSF hcrt-1 cutoff < 88 pg/mL Study populations are combined (same laboratory) |
| Dauvilliers et al (2003)6 | 1 (1/1HLA+) | 8 (7/8HLA+) | 0 | 64* | 11 | 100 | 100 | 89 | normal mean CSF hcrt-1 = 363 pg/mL low CSF hcrt-1 cutoff <108 pg/mL *linked to Stanford normal controls by reference CSF samples |
CSF hcrt-1 (cerebrospinal fluid, hypocretin-1 level), sens. (sensitivity), spec. (specificity), PPV (positive predictive value), NPV (negative predictive value). ICSD-2 (International Classification of Sleep Disorders, 2nd edition, 2005), HLA+ (HLA-DQB1*0602-positive)