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. 2010 Feb 2;5:7–18. doi: 10.2147/cia.s5476

Table 5.

Suggestions for monitoring febuxostat therapy

  1. After 4 weeks: CBC; serum creatinine; serum urate; ALAT; ASAT; 24-hour urate and creatinine clearance

  2. After 12 weeks and every 8 weeks thereafter: CBC; serum creatinine; serum urate; ALAT; ASAT; 24-hour urate and creatine clearance

  3. After 6 months and every 6 months thereafter: TSH

  4. Urate target according to BSR: <0.30 mmol/L is preferred, if not attainable then target according to EULAR: <0.36 mmol/L or any target at which the patient is free of gout flares

  5. If sUr target free of flares cannot be reached by administering febuxostat monotherapy, combination therapy may be considered with a uricosuric

  6. In case of ineffectivity (defined as not reaching the predefined target) of febuxostat, it should be stopped

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BSR, British Society for Rheumatology; CBC, complete blood count; EULAR, European League Against Rheumtaology; sUr, serum urate; TSH, thyroid-stimulating hormone.