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. Author manuscript; available in PMC: 2010 Feb 9.
Published in final edited form as: J Alzheimers Dis. 2008 Feb;13(1):1. doi: 10.3233/jad-2008-13101

Fig. 1.

Fig. 1

Cleavage of hAPP at Asp664 in vivo is abolished in PDAPP(D664A) transgenic mice. A rabbit antibody specific for the neoepitope generated after cleavage of AβPP at Asp664, APPNeo [2,12,15–17,63], was used to stain hippocampal sections of a, non-transgenic; b, PDAPP transgenic and c, PDAPP(D664A) transgenic mice. d, APPNeo antiserum was replaced by preimmune sera.