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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Bone. 2009 Jul 8;46(1):4. doi: 10.1016/j.bone.2009.06.029

Figure 1.

Figure 1

A) 5-hydroxytryptamine (5-HT) signaling within the central nervous system. 5-HT is synthesized by presynaptic neurons and stored in vesicles. Vesicles bind with the cell membrane following a stimulus to release 5-HT into the synaptic cleft via exocytosis. Released 5-HT activates post-synaptic receptors to stimulate the post-synaptic neuron. Membrane-bound 5-HT transporters (5-HTT) uptake released 5-HT to control the duration of 5-HT effects and recycle or degrade 5-HT. B) The effects of 5-HTT inhibition using a selective serotonin reuptake inhibitor (SSRI) on 5-HT signaling. Inhibition of the 5-HTT prevents uptake of 5-HT from resulting in its accumulation within the synaptic cleft and the prolonging receptor activation.