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The active site of HCA II in a ball-and-stick diagram taken from ref [15]. The zinc ion and the oxygen molecules of water molecules are shown as black and red spheres, respectively. The water network of the active-site is labeled W1, W2, etc. and WDW is the deep water. Hydrogen bonds involving solvent molecules are represented as dashed red lines. The dual conformation of the His64 side chain is shown in both inward and outward conformations.
