Table 2.
Details of Translocations detected following SAHA treatment
| SAHA Treatment |
Site | Chr. | MLL microhomology partner |
|---|---|---|---|
| 0.0 μM | 6766 | 6 | ATCTTCCCATGTTCAACTCCTCTT |
| 0.0 μM | 6807 | 20 | TGAGCCAAGGTCACACC |
| 0.0 μM | 6807 | 2 | CTGTTGTGAGCCAGGGCATT |
| 0.0 μM | 6894 | 5 | TGTTGTGAGCTCTCATATG |
| 0.5 μM | 6805 | 4 | TGTGAGTACAAACCAAG |
| 0.5 μM | 6852 | 1 | GCCCTCTGGAGGATGGTGGT |
| 0.5 μM | 6816 | 4 | TGTGAGTACAAACCAAGGAAAGTGG |
| 0.5 μM | 6807 | 14 | TGTTGTGAGCCTACGTTC |
| 0.5 μM | 6804 | 5 | TTGTGAATCTGGAA |
| 2.0 μM | 6719 | 5 | ATGGTTTTGCAATGG |
| 2.0 μM | 6805 | 1 | TTGTGAGATTCTAGC |
| 2.0 μM | 6806 | 1 | TCTGTTGTGAGCCACCAG |
| 2.0 μM | 6806 | 18 | TCTGTTGTGAGCCACTGCAC |
| 2.0 μM | 6807 | 13 | TGAGCCAAAACAGGA |
| 2.0 μM | 6789 | 2 | TGTGTATTGAGCCATG |
| 2.0 μM | 6759 | 20 | ACTTCTATCTATTTTATGTC |
| 2.0 μM | 6809 | 3 | GTGAGCCCTGTCTCCACT |
| 2.0 μM | 6807 | 10 | CTGTTGTGAGCAGTCGATG |
The site of break in the MLL-BCR for various rearrangements is listed. The microhomology between the MLL and partner chromosome is boldface. The sequence of the partner sequence is underlined.