Figure 2.

(a) Percentages of detached trophozoites in small intestinal explants from Giardia-infected mice after 30 min of ex vivo treatment with 40 µM formononetin or solvent control (DMSO). Each bar represents the mean of 10 explants; standard deviations are also shown. *Percentages are significantly different compared with the solvent control; P < 0.05, Mann–Whitney test. (b) Formononetin decreases the number of trophozoites in small intestines of mice compared with the solvent control. At time 0, Giardia-infected mice were treated orally with 0.235 mg/g formononetin or with the solvent control and the numbers of trophozoites in the small intestines were counted 1.5, 3 and 18 h later. The bar graph is representative of two independent experiments with up to four mice per condition.