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. Author manuscript; available in PMC: 2010 Oct 15.
Published in final edited form as: Org Lett. 2009 Oct 15;11(20):4596. doi: 10.1021/ol901870n

Figure 6.

Figure 6

Reductive cross-coupling reactions of aliphatic imines with allenic alcohols.

Reaction conditions: a Imine (2.0 equiv), Ti(Oi-Pr)4 (2.0 equiv), n-BuLi (4.0 equiv), THF, −78 °C - rt 1 h; recool to −78 °C, add Li-alkoxide of allenyl alcohol (1.0 equiv) in THF, −78 °C to rt (10 min), then warm to 60 °C. b Imine (2.0 equiv), Ti(Oi-Pr)4 (2.0 equiv), n-BuLi (4.0 equiv), THF, −78 °C - rt 1 h; recool to −78 °C and add Li-alkoxide of allenyl alcohol (1.0 equiv) in THF, −78 °C to rt.