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Affinity binding between peptide ligand and diffusible protein in PEGDA macromer solution (A) and in PEG hydrogel after photopolymerization (B). The binding was initially high when both the protein and affinity peptide are freely diffusible. However, once the PEGDA macromers are crosslinked into gels, the steric hindrance of polyacrylate kinetic chains and hydrophilic PEG chains decreases the binding of soluble protein to the immobilized affinity peptides.
