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. 2010 Jan 4;17(1):23–35. doi: 10.1093/dnares/dsp027

Figure 1.

Figure 1

Properties of naked DNA loops attached to the NM. (A) Drawing illustrating the local topology along a typical supercoiled DNA loop that correlates with both distance relative to the NM and sensitivity to DNase I. (B) Phase contrast micrograph showing the NM of a hepatocyte nucleoid. (C) Fluorescence micrograph showing the DNA halo around the NM of a hepatocyte nucleoid caused by the unwinding of the supercoiled DNA loops by treatment of the nucleoid with the DNA-intercalating agent ethidium bromide (80 µg/ml). Scale bars 10 µm.