Figure 2.

SO–OSNs respond to structurally diverse odorants over a wide concentration range. A, A single neuron responded to five odorants at 1 μm each under voltage-clamp conditions (left column, holding potential is −65 mV) and current-clamp conditions (right column, resting membrane potential is near −65 mV). The arrowheads mark action potentials generated under voltage-clamp mode due to imperfect space clamp. The gray trace (Ringer) was the mechanical response induced by a Ringer puff that was delivered with the same pressure as the odorant puffs. B, Dose–response curves for octanoic acid, amyl acetate, and (+) camphor between 10⁻¹² and 10⁻⁴ m. Each colored line (and the corresponding symbols) represents the data from a single cell, and the thick black line represents the averaged curve from all neurons shown in the same graph. Error bars indicate SEM. The holding potential was −65 mV for all neurons.