Figure 7.

SO–OSNs expressing the ΔSR1 allele show diverse patterns of odorant responses. A, Image under fluorescent illumination of the SO from a ΔSR1–RFP mouse. Scale bar, 5 μm. Because RFP is not fused to the tau protein, OSN cilia are not visible. B, Under voltage-clamp mode, ΔSR1–RFP neurons were stimulated by the same set of five odorants tested in the SR1–GFP cells. Cell 1 (left column) did not respond to any odorant including Mix 1. Cell 2 (middle column) responded to one of the five odorants. Note that this neuron also responded to Mix 1, which does not contain (+) camphor. Cell 3 (right column) responded to all five odorants. The holding potential was −65 mV for all neurons. The gray trace (Ringer) in each cell was the mechanical response induced by a Ringer puff that was delivered with the same pressure as the odorant puffs.