Table 1.
Urinary and fecal elimination of 60Co following IV administration in F344 rats: Effect of oral versus IV administered chelators (expressed as average % administered radioactivity ± SD).
| Control (n=12) |
Oral ReadiSorb (n=5) |
Oral GSH (n=6) |
IV GSH (n=4) |
Oral Cys (n=6) |
IV Cys (n=4) |
IV His (n=3) |
|
|---|---|---|---|---|---|---|---|
| Urine | |||||||
| Day 1 | 62.5 ± 5.4 | 64.8 ± 5.7 | 57.4 ± 11.7 | 80.9 ± 2.7a | 67.7 ± 7.7 | 77.2 ± 8.1a | 66.2b |
| Day 2 | 7.4 ± 1.3 | 5.6 ± 2.2 | 6.7 ± 2.5 | 7.3 ± 1.2 | 7.79 ± 0.69 | 6.8 ± 1.7 | 8.13 ± 0.26 |
| Day 3 | 1.92 ± 0.23 | 1.49 ± 0.21 | 2.3 ± 1.5 | 1.66 ± 0.39 | 1.79 ± 0.23 | 1.50 ± 0.08 | 1.95 ± 013 |
| Day 4 | 0.98 ± 0.12 | 1.03 ± 0.75 | 1.34 ± 0.61 | 0.44 ± 0.41 | 0.79 ± 0.07 | 0.89 ± 0.43 | 1.36 ± 0.08 |
| Day 5 | 0.56 ± 0.18 | 0.77 ± 0.53 | 0.87 ± 0.58 | 0.24 ± 0.20 | 0.58 ± 0.15 | 0.30 ± 0.10 | 0.95 ± 0.25 |
| Feces | |||||||
| Day 1 | 3.32 ± 0.79 | 4.1 ± 1.7 | 3.9 ± 1.1 | 1.54 ± 0.32 | 3.71 ± 0.72 | 1.8 ± 1.4 | 5.1 ± 1.1 |
| Day 2 | 2.9 ± 1.2 | 1.90 ± 0.21 | 2.6 ± 1.7 | 1.59 ± 0.25 | 1.86 ± 0.49 | 1.78 ± 0.69 | 2.90 ± 0.03 |
| Day 3 | 1.47 ± 0.58 | 0.94 ± 0.21 | 1.41 ± 0.66 | 0.89 ± 0.08 | 0.97 ± 0.35 | 0.95 ± 0.22 | 1.23 ± 0.17 |
| Day 4 | 0.77 ± 0.21 | 0.50 ± 0.19 | 0.67 ± 0.11 | 0.32 ± 0.15 | 0.39 ± 0.10 | 0.42 ± 0.24 | 0.76 ± 0.03 |
| Day 5 | 0.49 ± 0.16 | 0.32 ± 0.12 | 0.45 ± 0.20 | 0.12 ± 0.03 | 0.28 ± 0.07 | 0.25 ± 0.11 | 0.33 ± 0.19 |
a
Statistically different from corresponding control group by two tailed t-test (P < 0.05).
b
Urine was collected from only two animals