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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Cancer Prev Res (Phila). 2009 Dec 1;2(12):1050–1058. doi: 10.1158/1940-6207.CAPR-09-0085

Fig. 1. The triterpenoids CDDO-EA and CDDO-Me and the rexinoids 268 and 4204 decrease proliferation in vivo.

Fig. 1

Eight wks after initiation of lung carcinogenesis with vinyl carbamate, A/J mice were fed powdered diet containing triterpenoids (80 and 800 mg triterpenoid per kg of diet for Me and EA, respectively) or rexinoids (80 and 100 mg 4204 or 268 per kg diet) for 8 wks (A) or 16 wks (B). At the end of the study, mice were injected with BrdU for 2 hrs, and lung sections were stained with a BrdU antibody. The number of BrdU+ cells in tumors and the total number of tumor cells per field were counted in two lung sections per mouse. Values shown are mean ± SEM of > 1,500 cells; n = 4 mice per group. *, P < 0.05 vs. control; **, P < 0.05 vs. both individual drugs.