Table 4.
CDDO-Me and LG268 regulate different genes after treatment with LPS
| Gene | CDDO-Me Fold change |
LG268 Fold change |
|
|---|---|---|---|
| Casp8 | 1.7 | 2.1 | |
| Ccl2 | 0.8 | 1.1 | |
| CEBPβ | 1.1 | 1.3 | |
| Chuk | 1.2 | 2.1 | |
| Clecsf9 | 1.7 | 1.7 | |
| Csf3 | 1.0 | 0.7 | |
| Cxcl10 | 0.6 | 1.7 | |
| IL12a | 0.9 | 1.6 | |
| IL1b | 0.7 | 0.5 | |
| IL-6 | 2.7 | 0.9 | |
| Irf1 | 1.4 | 2.0 | |
| Ly86 | 1.0 | 1.6 | |
| Ly96 | 1.6 | 1.7 | |
| Map3k1 | 1.0 | 1.7 | |
| Map3k14 | 1.0 | 1.6 | |
| Map3k7 | 1.0 | 1.5 | |
| Map3k7ip1 | 1.0 | 2.1 | |
| Mapk14 | 1.2 | 1.5 | |
| Nfkb2 | 1.3 | 1.5 | |
| Prkra | 1.0 | 1.6 | |
| Ptgs2 | 1.6 | 0.7 | |
| Tbk1 | 1.1 | 1.8 | |
| Tlr4 | 1.0 | 2.2 | |
| Tlr7 | 0.8 | 1.5 | |
| TNF | 0.9 | 1.1 | |
| Tollip | 1.4 | 2.0 | |
| Ube2v1 | 1.0 | 1.6 | |
RAW264.7 cells were treated with 5 ng/ml LPS and either 300 nmol/L CDDO-Methyl ester (CDDO-Me) or 1000 nmol/L LG100268 (268) for 16 hours. Total RNA from these cells was analyzed using a mouse TLR signaling pathway DNA microarray. The listed fold changes are relative to LPS stimulated control samples.