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LPO-induced degradation of linoleic acid. HNE and ONE undergo phase I and phase II metabolism, resulting in the excretion of MA conjugates including HNE-MA, ONO-MA, and DHN-MA. DHN-MA may originate from DHN-GSH and possibly ONO-GSH, but it is shown as a metabolite of HNE-MA and ONO-MA for simplicity.
