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(A) Plot of the number of nonsynonymous substitutions per nonsynonymous site (dN) against the number of synonymous substitutions per synonymous site (dS) for pairwise comparisons among: (1) 132 orthologous protein-coding genes of Variola virus (VARV; red); and (2) complete polyprotein genes of North American West Nile virus (WNV; green). (B) Mean dN/dS in pairwise comparisons of VARV, WNV, and Hepatitis C virus 1a (HCV-1a).
