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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Osteoarthritis Cartilage. 2009 Sep 22;18(2):249. doi: 10.1016/j.joca.2009.09.002

Figure 2.

Figure 2

Biosynthetic response of chondrocytes in agarose culture to 24 hours of dynamic compression (1.0 Hz, 2.5% amplitude) in the presence of small-molecule integrin blockers PF001, PF002, PF003 (200uM). Data were normalized by the averaged untreated free-swell control for each animal. Data shown as mean ± 95% confidence interval (CI), n = 6-19 disks from 2-6 animals (PF001 n=6, PF002 n=6, PF003 n=19). Sulfate incorporation as measured by radiolabel incorporation. Glycosaminoglycan (GAG) accumulation as measured by DMMB dye binding assay. *** p<0.0005 relative to free-swell, + p<0.0005 relative to untreated controls.