Skip to main content
. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Osteoarthritis Cartilage. 2009 Sep 22;18(2):249. doi: 10.1016/j.joca.2009.09.002

Figure 3.

Figure 3

Effects of broad spectrum integrin antagonists PF001 and echistatin in free-swelling culture (A) and on dynamic compression stimulation of agarose cultures (B). Data shown as mean ± 95%CI. (A) Sulfate incorporation and GAG content in free-swell relative to untreated controls. n = 6-51 samples from 2-11 animals (control n=51, PF001 n=6, echistatin n=7), ***p<0.0005 relative to untreated control. (B) Proteoglycan synthesis as indicated by sulfate incorporation and GAG content with dynamic compression relative to treated free-swell controls. n = 6-13 samples from 2-4 animals (control n=13, PF001 n=6, echistatin n=7), ***p<0.0005 relative to 1 (no change relative to free-swell).