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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Osteoarthritis Cartilage. 2009 Sep 22;18(2):249. doi: 10.1016/j.joca.2009.09.002

Figure 5.

Figure 5

Effects of blocking α5β1 integrins on agarose cultures in free-swelling culture and in response to dynamic compression. Data shown as mean ± 95%CI. (A) Sulfate incorporation and GAG content in free-swelling agarose cultures relative to untreated controls. n = 3-51 samples from 1-11 animals (control n=51, PF002 n=6, α5 n=6, 5 μg/mL β1 n=6, 10μg/mL β1 n=3), ***p<0.0005 relative to untreated controls. (B) Proteoglycan synthesis (sulfate incorporation and GAG content) response after 24 hours of dynamic compression relative to respective treated free-swell controls. n = 3-12 samples from 1-4 animals (control n=12, PF002 n=6, α5 n=6, 5 μg/mL β1 n=6, 10μg/mL β1 n=3). ***p<0.0005, **p=0.001, *p=0.023 relative to 1 (no change compared to free-swell).