Figure 5.

Visualization of a self organizing dyad-pairs network map of 32,000 elements using the Gene Expression Dynamics Inspector. Plotting the dyad ratios as a GEDI in benign prostate tissue enables rapid visualization of the ratios of the same dyad pairs in early tumor and invasive prostate tumors. Each point represents the same dyad pair in three different tissue states. Network size does not change significantly until the metastatic state is reached. Visualization shows that the dyad pairs begin to change color relative to the benign state even in the primary tumor. While there may not be an appreciable change in the number of genes passing the limiting coefficient of variation in the early stages of disease, subtle changes in the covariance between gene pairs are evident.