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. Author manuscript; available in PMC: 2011 Feb 11.
Published in final edited form as: J Med Chem. 2010 Feb 11;53(3):933. doi: 10.1021/jm901039z

Figure 6.

Figure 6

Comparative studies of four 18F PET imaging agents (10, AV-45; 23, AV-138; 24, AV-144 and 25, AV-19) targeting Aβ plaques in living human brain - AD (Alzheimer’s disease); HC (healthy control). The scale for the Y axis represents SUV value. By visual inspection one can easily translate the specific vs non-specific binding ratio in different regions of the brain. Three PET imaging tracers, 10, AV-45; 23, AV-138; and 24, AV-144, displayed the desired properties for detecting Aβ plaques in the brain of AD patients. One final candidate, 10, AV-45, was selected for commercial development.