. Author manuscript; available in PMC: 2011 Feb 1.

Published in final edited form as: Curr Opin Pharmacol. 2009 Oct 25;10(1):80. doi: 10.1016/j.coph.2009.09.009

Table 2.

Changes in cannabinoid receptor levels in nervous system during neuropathic pain

Pain Model	Region examined (all ipsilateral, unless specified)	Receptor	Direction of change
Paw inflammation	Spinal cord, dorsal horn	CB₂R	↔^b [70]
Chronic constriction injury	Spinal cord, dorsal horn	CB₁R	↑^a [39]
		CB₂R	↑ [70]
Axotomy of sciatic nerve (tibial branch)	Contralateral thalamus	CB₁R	↑ [42]
Lumbar spinal nerve ligation	DRG	CB₁R	↑ [40]
		CB₂R	↑ [70]
Partial saphenous nerve ligation	Spinal cord, dorsal horn	CB₁R	↑ [41]
		CB₂R	↑ [41]
	DRG	CB₁R	↑ [41]
		CB₂R	↑ [41]

↑, increase;

↔, no change