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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Brain Behav Immun. 2009 Oct 12;24(2):254. doi: 10.1016/j.bbi.2009.10.005

Fig. 2A.

Fig. 2A

Peripheral E. coli treatment induced a protracted IL-1β protein response in the hippocampus of 24 mo animals. 3 mo and 24 mo animals were administered E. coli or vehicle i.p. 4 d post-treatment, animals underwent contextual fear conditioning or served as HCC. 30 min post-conditioning, hippocampal IL-1β was measured. Peripheral E. coli treatment increased IL-1β protein in 24 mo animals compared to all other experimental groups (*** p < .001). E. coli treatment had no effect on IL-1β in 3 mo animals. N = 4 animals/group.