Table 1.
Adjusted association of 6 SNPs with noncardioembolic stroke in VSR
| SNP ID | Casea | Controla | Model 1 | Model 2 | |||
|---|---|---|---|---|---|---|---|
| OR and 90% CI | p | qb | OR and 90% CI | p | |||
| MYH15 rs3900940 | |||||||
| CC + CT | 281 (55.6) | 390 (49.8) | 1.31 (1.07–1.60) | 0.01 | 0.06 | 1.25 (1.00–1.56) | 0.05 |
| CC | 56 (11.1) | 72 (9.2) | 1.50 (1.06–2.11) | 0.03 | 1.19 (0.80–1.75) | 0.24 | |
| CT | 225 (44.5) | 318 (40.6) | 1.27 (1.03–1.56) | 0.03 | 1.26 (1.00–1.59) | 0.05 | |
| TT | 225 (44.5) | 394 (50.3) | ref. | ref. | |||
| KIF6 rs20455 | |||||||
| GG + GA | 327 (64.8) | 475 (60.7) | 1.24 (1.01–1.52) | 0.05 | 0.12 | 1.23 (0.98–1.54) | 0.07 |
| GG | 73 (14.5) | 102 (13.0) | 1.24 (0.91–1.69) | 0.13 | 1.30 (0.93–1.83) | 0.10 | |
| GA | 254 (50.3) | 373 (47.7) | 1.24 (1.00–1.53) | 0.05 | 1.20 (0.95–1.53) | 0.10 | |
| AA | 178 (35.3) | 307 (39.3) | ref. | ref. | |||
| VAMP8 rs1010 | |||||||
| CC + CT | 326 (64.4) | 483 (61.6) | 1.21 (0.99–1.49) | 0.06 | 0.12 | 1.33 (1.06–1.67) | 0.02 |
| CC | 77 (15.2) | 112 (14.3) | 1.27 (0.93–1.72) | 0.10 | 1.37 (0.98–1.91) | 0.06 | |
| CT | 249 (49.2) | 371 (47.3) | 1.20 (0.96–1.49) | 0.09 | 1.32 (1.04–1.68) | 0.03 | |
| TT | 180 (35.6) | 301 (38.4) | ref. | ref. | |||
| 9p21 rs10757274 | |||||||
| GG + GA | 386 (76.7) | 568 (72.4) | 1.20 (0.95–1.50) | 0.10 | 0.15 | 1.14 (0.89–1.46) | 0.20 |
| GG | 139 (27.6) | 154 (19.6) | 1.59 (1.20–2.11) | 0.004 | 1.45 (1.06–1.98) | 0.03 | |
| GA | 247 (49.1) | 414 (52.8) | 1.05 (0.82–1.34) | 0.38 | 1.02 (0.78–1.33) | 0.45 | |
| AA | 117 (23.3) | 216 (27.6) | ref. | ref. | |||
| SNX19 rs2298566 | |||||||
| CC + AC | 473 (94.5) | 744 (94.9) | 0.93 (0.61–1.43) | 0.61 | 0.73 | 0.88 (0.55–1.40) | 0.68 |
| CC | 294 (58.1) | 456 (58.2) | 0.97 (0.63–1.50) | 0.55 | 0.95 (0.59–1.53) | 0.57 | |
| AC | 179 (35.4) | 288 (36.7) | 0.87 (0.56–1.37) | 0.69 | 0.77 (0.48–1.26) | 0.81 | |
| AA | 33 (6.5) | 40 (5.1) | ref. | ref. | |||
| PALLD rs7439293 | |||||||
| AA + GA | 425 (84.3) | 667 (85.4) | 0.89 (0.68–1.17) | 0.76 | 0.76 | 0.92 (0.67–1.25) | 0.68 |
| AA | 201 (39.9) | 290 (37.1) | 0.94 (0.70–1.27) | 0.63 | 1.02 (0.73–1.42) | 0.46 | |
| GA | 224 (44.4) | 377 (48.3) | 0.85 (0.63–1.14) | 0.83 | 0.84 (0.60–1.16) | 0.81 | |
| GG | 79 (15.7) | 114 (14.6) | ref. | ref. | |||
Model 1 was adjusted for age and sex. Model 2 was adjusted for age, sex, smoking, hypertension, diabetes, dyslipidemia, and BMI. Values in parentheses indicate percentages or 95% CI.
a
Individuals with missing genotype or traditional risk factor information were excluded.
b
False discovery rate q value.