Table 1.
Baseline Demographics, Respiratory Function, and Emphysema Distribution*
| All Patients |
Substudy Patients |
|||
|---|---|---|---|---|
| Characteristics | LVRS(n = 608) | Medical(n = 610) | LVRS(n = 116) | Medical(n = 122) |
| Age at randomization, yr | 66.5 ± 6.3 | 66.7 ± 5.9 | 66.2 ± 7.2 | 66.0 ± 6.4 |
| Male gender, % | 58.4 | 64.1 | 62.1 | 71.3 |
| BMI, kg/m2 | 24.5 ± 3.7 | 24.7 ± 3.5 | 24.4 ± 3.7 | 24.7 ± 3.6 |
| Pao2, mm Hg | 64.5 ± 10.5 | 64.2 ± 10.1 | 62.9 ± 11.8 | 62.6 ± 10.2 |
| Paco2, mm Hg | 43.3 ± 5.9 | 43.0 ± 5.8 | 41.8 ± 5.2 | 42.4 ± 5.7 |
| PH | 7.42 ± 0.03 | 7.42 ± 0.03 | 7.43 ± 0.03 | 7.42 ± 0.03 |
| FEV1, L | 0.76 ± 0.24 | 0.78 ± 0.24 | 0.76 ± 0.24 | 0.80 ± 0.26 |
| FEV1, % predicted | 26.8 ± 7.4 | 26.7 ± 7.0 | 26.7 ± 7.6 | 27.1 ± 7.1 |
| RV, % predicted | 220.5 ± 49.9 | 223.3 ± 48.9 | 218.3 ± 52.2 | 219.8 ± 49.2 |
| TLC, % predicted | 128.0 ± 15.3 | 128.5 ± 15.0 | 128.3 ± 15.1 | 127.7 ± 14.2 |
| Dlco, % predicted | 28.3 ± 9.7 | 28.4 ± 9.7 | 27.7 ± 10.3 | 29.1 ± 8.9 |
| Hgb, g/dL | 14.4 ± 1.3 | 14.3 ± 1.3 | 14.4 ± 1.5 | 14.2 ± 1.3 |
| Emphysema location,† % | ||||
| Upper lobe | 67.7 ± 21.9 | 69.9 ± 20.8 | 69.1 ± 23.1 | 67.7 ± 22.4 |
| Lower lobe | 49.8 ± 18.4 | 51.5 ± 17.8 | 54.1 ± 18.4 | 52.3 ± 19.0 |
| Total | 55.8 ± 15.9 | 57.6 ± 15.3 | 59.1 ± 15.8 | 57.4 ± 16.8 |
| Upper lobe-predominant,‡ % | 63.3 | 66.5 | 62.1 | 55.4 |
*Values are given as the mean ± SD, unless otherwise indicated. BMI = body mass index; Hgb = hemoglobin; pH = arterial pH; RV = residual volume; TLC = total lung capacity.
†Determined from radiologist scores (0 to 4) for the percentage of emphysema seen on chest CT scans, in each of the upper, middle, and lower zones of each lung. The upper lobe percentage is the mean of the midpoints of the ranges represented by the right and left upper lobe scores. The lower-lobe percentage is the mean of the midpoints of the ranges represented by the right and left middle and lower lobe scores. The total percentage is the mean of the midpoints of the ranges represented by the upper, middle, and lower lobe scores of both lungs.
‡Determined from the radiologist's assessment of the craniocaudal distribution of emphysema seen on chest CT scans. The choices were upper lobe-predominant, lower lobe-predominant, diffuse, or superior segments of lower lobes predominantly involved. The latter three choices were grouped as non–upper lobe-predominant.