Table 2.
Linear Regression of Systolic and Diastolic Blood Pressure, Modeled on Five Brain Pathologic Measures Jointly*
| Age-at-entry 65–80 years (n=137) | Age-at-entry > 80 years (n=91) | |||||
|---|---|---|---|---|---|---|
| Number (%),or mean (± SD) for Braak stage |
Coefficient for SBP (95%CI)† |
Coefficient for DBP (95%CI)† |
Number (%), or mean (SD) for Braak stage |
Coefficient for SBP (95%CI)† |
Coefficient for DBP (95%CI)† |
|
| Microinfarct > 2 | 28 (20) | 11.5 (1.7, 21.3)‡ | −1.7 (−6.3, 3.0) | 22 (24) | 3.7 (−9.5, 16.8) | 2.1 (−2.8, 7.1) |
| Cystic macroinfarct | 38 (28) | −1.3 (−10.1, 7.5) | −0.7 (−4.8, 3.5) | 23 (25) | 4.6 (−8.7, 17.9) | −0.7 (−5.7, 4.2) |
| Braak stage (0–VI) | 2.7 (1.8) | −0.8 (−3.6, 2.0) | −0.4 (−1.7, 0.9) | 3.2 (1.6) | −2.4 (−6.4, 1.5) | −0.2 (−1.6, 1.3) |
| CERAD B or C | 50 (36) | −5.7 (−15.2, 3.9) | 0.7 (−3.8, 5.2) | 37 (41) | 0.8 (−12.2, 13.9) | 1.6 (−3.3, 6.5) |
| Lewy bodies | 36 (26) | 6.8 (−2.1, 15.7) | 1.2 (−3.0, 5.4) | 34 (37) | −2.4 (−13.5, 8.7) | 1.6 (−2.6, 5.8) |
*
Adjusted for age-at-entry, time to death and gender
†
Coefficients represent estimated mean differences in blood pressure by the presence versus absence of the pathologic measure, except for Braak Stage where the coefficient represents the slope of an increase in Braak stage per increase in 1 mmHg of blood pressure
‡
p < 0.05.