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. Author manuscript; available in PMC: 2010 Feb 9.
Published in final edited form as: Am J Med Genet A. 2006 Sep 15;140(18):1973. doi: 10.1002/ajmg.a.31397

Fig. 2.

Fig. 2

FISH analysis of (A–C) DiGeorge/Velocardiofacial (DG/VCF) Syndrome and (D) SOX10 duplication. Metaphase chromosomes derived from the balanced t(11;22) carrier patient hybridized to different fluorescently labeled probes. A: LSI 22q11.2-deletion probe (red) specific for HIRA is present on the normal 22 and der(22), while the control probe specific for ARSA (green) localizes to 22q13.3 on the normal 22 and der(11). B: BAC XX-91C (green) specific for the DG/VCF-associated gene TBX1 is present on the normal 22 and der(22) and not on the normal 11 or der(11) (red). C: BAC RP11-251M9 (green) specific for the DG/VCF-II region is present in 10p14 of both chromosome 10 (red) homologues. The results of A–C indicate that none of the common DG/VCF regions were deleted in the propositus. D: Single copy signals of fosmid probe WI2-1412L4 (green) are on the normal 22 and the der(11) as indicated by centromere 11-specific probe (red). Similar results were obtained with fosmids WI2-1157M7 and WI2-1323A3. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]