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. Author manuscript; available in PMC: 2011 Feb 15.
Published in final edited form as: Neuroimage. 2009 Nov 14;49(4):3436. doi: 10.1016/j.neuroimage.2009.11.019

Table 3. Spatial distribution of correlation of WMH volume with brain functional MRI activation during sDSST task performance.

Regions that show correlation between the structural measure (WMH measure) and task (sDSST > control condition) adjusted for atrophy index and group assignment, including the size of cluster, the maximum Z statistic for the cluster and the location of the maximum Z statistic in Talairach coordinates. The corrected alpha is the probability of a false positive detection based on the combination of individual voxel probability thresholding and minimum cluster size thresholding.

Regions Cluster
Size		 Peak Z-
Score		 Talairach Coordinate
for Peak Z-Score
Regions Negatively Correlated with WMH burden
Left anterior cingulate cortex 524 4.05 −3.96, −1.25, 52.561
Right anterior cingulate cortex 561 3.95 19.8, −17.58, 36.82
Left prefrontal cortex 885 4.19 −23.76, −7.61, 41.833
Right prefrontal cortex 1976 4.63 29.7, −9.55, 41.934
Regions positively correlated with WMH burden
No significant voxels
1

This cluster had its peak in the left medial frontal gyrus (BA 6) covered the cingulate gyrus (BA 24, 32) and superior frontal gyrus (BA 6).

2

This cluster had its peak in the right cingulate gyrus (BA 24, 32) extended to medial frontal gyrus and superior frontal gyrus (BA 6).

3

This cluster had its peak in the left middle frontal gyrus and covered the sensori-motor cortex (pre- and post-central gyri: BA 3, 40, 43, 44).

4

This cluster had its peak in the right middle frontal gyrus (BA 6) covered the sensori-motor cortex (pre- and post-central gyri: BA 3, 4, 6, 40, 43, 44), superior frontal gyrus (BA 6) and superior temporal gyrus (BA 42).