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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2010 Jan–Feb;1799(1-2):119. doi: 10.1016/j.bbagrm.2009.11.008

Figure 13.

Figure 13

HMGB1 Stimulates APE1 Incision Activity in the Context of CAG Repeat. APE1 (0.1 nM) incision activity on a synthesized abasic site (THF) imbedded in CAG repeats is significantly increased by increasing concentrations of HMGB1 (Lane 2–5). Lane 1 represents APE1 (0.1 nM) incision in the absence of HMGB1. Lane 2–5 represents APE1 incision in the presence of 10, 20, 50 and 100 nM HMGB1, respectively. Substrate and product are indicated by arrows. The quantification of APE1 incision product is illustrated in lower panel.