Table 3.
Multivariable-adjusted* odds ratios of functional outcomes after stroke and stroke subtypes according to alcohol consumption in the Physicians’ Health Study (N=21,862).
| No TIA or stroke |
MRS 0–1 | MRS 2–3 | MRS 4–6 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total Stroke | |||||||||||
| (n = 426) | (n = 709) | (n = 258) | |||||||||
| N | % | N | % | RR (95% CI) |
N | % | RR (95% CI) |
N | % | RR (95% CI) |
|
| <1 drink/wk | 5122 | 26.0 | 110 | 25.8 | 1.00 | 193 | 27.2 | 1.00 | 78 | 30.2 | 1.00 |
| 1 drink /wk | 2823 | 14.3 | 45 | 10.6 | 0.85 (0.60, 1.21) |
79 | 11.1 | 0.84 (0.64, 1.10) |
22 | 8.5 | 0.60 (0.37, 0.97) |
| 2–4 drinks/wk | 4460 | 22.6 | 90 | 21.1 | 1.13 (0.85, 1.50) |
130 | 18.3 | 0.91 (0.72, 1.15) |
56 | 21.7 | 1.02 (0.72, 1.45) |
| 5–6 drinks/wk | 2502 | 12.7 | 56 | 13.1 | 1.17 (0.84, 1.63) |
99 | 14.0 | 1.16 (0.90, 1.49) |
27 | 10.5 | 0.80 (0.51, 1.25) |
| ≥1 drink/day | 4795 | 24.3 | 125 | 29.3 | 1.09 (0.84, 1.42) |
208 | 29.3 | 1.03 (0.84, 1.26) |
75 | 29.1 | 0.86 (0.62, 1.19) |
| Ischemic Stroke | |||||||||||
| (n = 393) | (n = 633) | (n = 131) | |||||||||
| <1 drink/wk | 5122 | 26.0 | 100 | 25.4 | 1.00 | 171 | 27.0 | 1.00 | 37 | 28.2 | 1.00 |
| 1 drink /wk | 2823 | 14.3 | 42 | 10.7 | 0.88 (0.61, 1.27) |
67 | 10.6 | 0.81 (0.61, 1.08) |
14 | 10.7 | 0.82 (0.44, 1.53) |
| 2–4 drinks/wk | 4460 | 22.6 | 82 | 20.9 | 1.14 (0.84, 1.54) |
110 | 17.4 | 0.88 (0.69, 1.12) |
34 | 26.0 | 1.36 (0.85, 2.20) |
| 5–6 drinks/wk | 2502 | 12.7 | 50 | 12.7 | 1.16 (0.82, 1.63) |
92 | 14.5 | 1.23 (0.94, 1.59) |
13 | 9.9 | 0.84 (0.44, 1.59) |
| ≥1 drink/day | 4795 | 24.3 | 119 | 30.3 | 1.13 (0.86, 1.49) |
193 | 30.5 | 1.07 (0.86, 1.32) |
33 | 25.2 | 0.79 (0.49, 1.28) |
| Hemorrhagic Stroke | |||||||||||
| (n =30) | (n =75) | (n =117) | |||||||||
| <1 drink/wk | 5122 | 26.0 | 8 | 26.7 | 1.00 | 22 | 29.3 | 1.00 | 36 | 30.8 | 1.00 |
| 1 drink /wk | 2823 | 14.3 | 3 | 10.0 | 0.72 (0.19, 2.72) |
12 | 16.0 | 1.06 (0.52, 2.15) |
8 | 6.8 | 0.45 (0.21, 0.98) |
| 2–4 drinks/wk | 4460 | 22.6 | 8 | 26.7 | 1.28 (0.47, 3.43) |
19 | 25.3 | 1.08 (0.58, 2.00) |
21 | 17.9 | 0.78 (0.45, 1.34) |
| 5–6 drinks/wk | 2502 | 12.7 | 5 | 16.7 | 1.39 (0.45, 4.29) |
7 | 9.3 | 0.68 (0.29, 1.60) |
13 | 11.1 | 0.80 (0.42, 1.51) |
| ≥1 drink/day | 4795 | 24.3 | 6 | 20.0 | 0.80 (0.27, 2.32) |
15 | 20.0 | 0.68 (0.35, 1.32) |
39 | 33.3 | 0.97 (0.62, 1.54) |
Comparison group consists of men without stroke or transient ischemic attack (TIA) who consumed <1 drink/wk alcohol. MRS refers to modified Rankin Scale; CI refers to confidence interval.
*
Adjusted for age, systolic blood pressure, treatment for hypertension, smoking, history of diabetes, body mass index, exercise, history of migraine, and TIA.