Figure 3.

Fundus photograph OS of a HIV-positive patient with CMV retinitis involving superotemporal macula with a serous retinal detachment (A) and corresponding FAF image showing hypoautofluorescence with a faint halo of hyperautofluorescence in the zone of hemorrhagic retinitis and retinal edema (B). Hyperautofluorescent stippling is also seen temporally (asterisk), and corresponds to a linear streak of advancing infection. Following intravitreal ganciclovir and foscarnet injections, the CMV retinitis began to resolve (C) with a corresponding decrease in the density of the hypoautofluorescence at the superotemporal arcade (D). The prior area of linear hyperautofluorescence now shows linear hyper- and hypoautofluorescence (asterisk). Clinically, this area of CMV retinitis is also resolving and has been replaced by punctate hemorrhages suggestive of small-vessel injury during the resolution phase of the disease.