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. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Nov 18;20(2):665. doi: 10.1016/j.bmcl.2009.11.056

Scheme 4.

Scheme 4

Reagents and conditions: (a) TFA, CH2Cl2, 0°C to RT, 3h, quant.; (b) 3,5-bis(CF3)PhCOCl, aq NaOH, RT, overnight, 74%; (c) NH2OH•HCl, pyridine, 3Å sieves, RT, overnight, 72%; (d) Na2CO3, p-TsCl, acetone, RT, 3 h, 66%; (e) 4-I-PhCl, MeNHCH2CH2NHMe, CuI, Cs2CO3, dioxane, 100 °C, 24 h, 48%.