Skip to main content
. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Nov 18;20(2):665. doi: 10.1016/j.bmcl.2009.11.056

Table 2.

Effects of aromatic substitution on transcription and cytotoxicity in transfected PC-3 cellsa

graphic file with name nihms163359t2.jpg
Cmpd R1 R2 IC50
SRE.L
(µM)		 % inh SRE.L
(10, 100 µM)		 % inh pRL-TK
(10, 100 µM)		 % inh WST-1
(10, 100 µM)
5a 3,5-bis(CF3) 4-Cl 4.7 71, 100 53, 89 42, 91
5b 3,5-bis(CF3) 3-Cl 5.9 65, 100 51, 89 49, 97
5c 3,5-bis(CF3) 4-H 36 13, 65 33, 59 0, 37
5d 3-CF3 4-Cl 27 25, 86 5, 19 0, 58
5e 4-CF3 4-Cl 29 26, 91 6, 0 0, 56
5f 4-H 4-Cl >100
5g 4-Cl 3,5-bis(CF3) 8.6 58, 100 19, 87 11, 96
a

Assays defined in Table 1.